Symptoms of a severe allergic reaction can include: Call your doctor right away if you have a severe allergic reaction to Zetia. Get answers to some frequently asked questions about Zetias side effects. Learn about the common, mild, and serious side effects it can cause and how to manage them. POTS is an unusual condition in which your heart rate speeds up by 30 or more beats per minute with little or no change in blood pressure. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The following information describes dosages that are commonly used or recommended. If you miss a dose of Zetia, you can take your missed dose as soon as you remember. . For more information about the effectiveness of Zetia for lowering your triglycerides, see the Zetia uses section above. These symptoms could be life threatening and require immediate medical care. Ezetimibe may be used alone or with other drugs (such as "statins" or . Most patients will need at least 64 to 80 ounces (8 to 10 cups) of hydrating liquids throughout the day, such as water, broth, juice, or decaffeinated tea. Zetia is contraindicated under the following conditions: Zetia tablets should be stored at a room temperature of 77F (25C) in a tightly sealed container away from light. Weight gain isnt a side effect reported in clinical studies of Zetia. Clinical studies have shown Zetia to be effective for treating primary high cholesterol when used alone or with statin drugs. Dont take an extra dose to make up for your missed dose. If you have questions about using Zetia and cholestyramine together, talk with your doctor. Before starting a new medication, its a good idea to talk with a healthcare professional about any questions or concerns you may have. Phase IV trials are used to detect adverse drug . This included relief of muscle pain, muscle weakness, and cramps. This is especially helpful to do when you first start taking new drugs or using a combination of treatments. The dosage is the same for all approved uses. You should store Zetia tablets at a room temperature of 77F (25C) in a tightly sealed container away from light. Zetia is primarily cleared from the body through fecal excretion. Your doctor will likely start you on the typical dosage approved to treat your condition. For more information, see the How Zetia works section below. Its not known how many adults and children experienced muscle pain in clinical studies of other conditions treated with Zetia and statin drugs. Therefore, you shouldnt breastfeed if youre taking Zetia with a statin drug. What are the more common side effects of Zetia? Have your doctor measure your heart rate sitting and standing. Total cholesterol was reduced by 12% more in children who took Zetia and simvastatin than children who took simvastatin alone. No, hair loss isnt a known side effect of Zetia. Liver problems. However, you may still experience muscle problems if you use Zetia alone. In the video she posted on Thursday, the "Real Housewives of New York City" alum detailed her suffering from a severe dehydration issue and shared that her doctor . If your muscle-related side effects dont go away or become severe, tell your doctor right away. Zetia may cause mild side effects other than the ones listed above. Zetia should be protected from moisture and shouldnt be stored in areas where it could get damp or wet, such as bathrooms. See the Mild side effects and Serious side effects sections above for more information. Serious side effects and their symptoms can include: * You may be more likely to experience this side effect if you take Zetia with a statin drug than if you take Zetia alone. Before taking Zetia, talk with your doctor about your health history. Chylomicrons help your body, low-density lipoproteins (LDL), sometimes referred to as bad cholesterol, high-density lipoproteins (HDL), sometimes referred to as good cholesterol, triglycerides, which are a type of fat that are building blocks of cholesterol, Apo B (high levels of this protein are a sign of high cholesterol), non-HDL cholesterol (calculated by subtracting your HDL cholesterol level from your total cholesterol), were reduced by an average of 13% to 14% in people who used Zetia, ranged from not changing to being reduced by an average of 1% in people who used a placebo, were reduced by an average of 18% in people who used Zetia, increased by an average of 1% in people who used a placebo, decreased by an average of 13% to 14% in people who used Zetia alone, decreased by an average of 15% to 40% in people who used a statin alone, depending on the statin used, decreased by an average of 24% to 46% in people who used Zetia and a statin, depending on the statin used, ranged from decreasing by an average to 1% to increasing by an average of 4% in people who took a placebo, decreased by an average of 19% to 20% in people who used Zetia alone, decreased by an average of 20% to 54% in people who used a statin alone, depending on the statin used, decreased by an average of 34% to 61% in people who used Zetia and a statin, depending on the statin used. Sometimes doctors will recommend taking both a statin medication and Zetia for high cholesterol. There are no known interactions between Zetia and alcohol. In addition, you may need to watch out for grapefruit. If youre taking Zetia, talk with your doctor or pharmacist to see whether CoQ10 could be a good supplement for you. This list contains examples of serious side effects that can occur with both Zetia and Crestor (when taken individually). If you and your doctor decide that Zetia treatment isnt right for you, you simply wont take any more doses. Talk with your doctor about your health history before you take Zetia. These tests will look at your cholesterol levels and also your liver enzyme levels. After stopping Zetia treatment, their liver enzymes levels went back down. Ways to reduce the symptoms. We talked to experts about, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Zetias mechanism of action is considered complementary to that of statins and fenofibrate. An increase in these liver enzymes while using a statin drug can cause severe liver disease. This is not a complete list of side effects and others may occur. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Crestor, or with both drugs (when taken individually). Zetia can cause certain side effects, some of which are more common than others. This may increase your risk of side effects. What are the serious side effects of Zetia? However, excessive alcohol use can damage your liver over time. Talk with your doctor about the risks of taking Zetia with warfarin. Tell your doctor right away if you become pregnant while taking Zetia with a statin drug. However, Zetia shouldnt be used with fibrate drugs other than fenofibrate. The heart beats faster to pump it up to the brain, but with little success. No, clinical studies havent shown Zetia to affect blood pressure. Below are examples of these side effects. Each type is described below in more detail. Learn more about some of the side effects that Zetia may cause. Talk with your doctor or pharmacist if you have trouble swallowing Zetia tablets. Increased liver enzymes can be a sign of liver damage. Learn about alternatives like new drugs, A new class of self-injectable medications are showing promise in treating high cholesterol. Call your doctor right away if you have serious side effects. You can take Zetia with or without food. Zetia is sometimes used with medications in the statin drug class. OI is a condition in which an excessively reduced volume of blood returns to the heart after an individual stands up from a lying down position. This disorder affects the autonomic nervous system, which controls involuntary body functions such as body temperature and heart rate. They can tell you about other medications that may work well for you. However, if the side effects last longer than . Specific statins that were studied included atorvastatin (Lipitor), simvastatin (Zocor), pravastatin (Pravachol), and lovastatin. Symptoms: This section is currently in development. For information on the effectiveness of Zetia, see the Zetia uses section below. They may suggest foods that can help lower your cholesterol and reduce your risk of weight gain. Zetia is a lipid-lowering compound used to treat high cholesterol.Common side effects of ezetimibe include diarrhea, abdominal pain, back pain, joint pain, muscle aches, and sinus infection ().. Serious side effects of ezetimibe include hypersensitivity reactions (including angioedema - swelling of the skin and underlying tissues of the head and neck - that can be life-threatening), skin rash . Zetia is also available in a generic form called ezetimibe. These side effects may be temporary, lasting a few days to weeks. The phase IV clinical study analyzes which people take Zetia and have Constipation. It only comes in a strength of 10 milligrams (mg). Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. Zetia and Crestor are both brand-name drugs. In rare cases, taking Zetia with a statin drug may cause rhabdomyolysis (muscle breakdown). It can cause mild side effects and, less commonly, serious side effects. Grapefruit can prevent the breakdown of statins in your body, which can raise your levels of these drugs and increase your risk of side effects. What causes POTS? But reviews and complaints about medications, including Zetia, may not be as reliable as other types of consumer reviews. If youre taking Zetia alone, you shouldnt need to take CoQ10. Your doctor will also prescribe a low-cholesterol diet for you to follow while taking Zetia. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. They can both be taken with or without food. See the Zetia prescribing information for details. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. The dose of Zetia used for children is the same as the adult dose. Lipitor is available in a generic form called atorvastatin. Also tell them about any vitamins, herbs, and supplements you use. However, your doctor will check your cholesterol levels about 4 weeks after you start treatment. Statins are drugs used to lower cholesterol. While there's no cure, several treatments and lifestyle changes can help manage the symptoms of POTS. Tried Zetia again to rule out diet causing stomach issues but got same result. stuffy nose. It also isnt known what percentage of adults and children experienced diarrhea in clinical studies of other conditions treated with Zetia. Zetias side effects are usually mild, especially if youre taking Zetia alone. Zetia may not be right for you if you have certain medical conditions or other factors affecting your health. Brand-name medications usually cost more than generics. LDL cholesterol was reduced by 15% more in children who took Zetia and simvastatin than in children who took simvastatin alone. Zetia is metabolized in the small intestine and liver. Also, Zetia use may cause increased liver enzyme levels, especially if its taken with a statin drug. Specifically, Zetia is used along with a low-cholesterol diet to treat: Zetia is approved to treat these conditions in certain situations. Read more about these alternatives to traditional statin, Having high cholesterol puts you at risk for a heart attack or stroke. Qu H, et al. There arent any herbs or supplements that have been specifically reported to interact with Zetia. These symptoms can be signs of an infection. Avoid eating foods high in fat or cholesterol, or Zetia will not be as effective. You can learn more about how we ensure our content is accurate and current by reading our. How long a medication remains good can depend on many factors, including how and where you store the medication. When this happens, more cholesterol can then be cleared from your blood by your liver. I am a stay at home mama to a sweet baby girl, and wife to an amazing h. Zetia generally costs less than Lipitor. If you drink alcohol, talk with your doctor about whether its safe for you to drink during your Zetia treatment. Cholesterol absorption inhibitors prevent your small intestine from absorbing cholesterol. Both Zetia and Crestor come as tablets that are swallowed. Cholesterol can also be found in foods such as eggs, cheese, and meat. You can use the study as a second opinion to make health care decisions. After first three days stopped it for two days. Zetia reduces the buildup of fats, cholesterol, and other substances on the artery walls (this process is known as atherosclerosis) and if taken long term it may reduce the risk of heart disease. (Mixed hyperlipidemia is also known as mixed high cholesterol.). Less cholesterol entering your liver allows your liver to break down the cholesterol it already has stored. Its not known if Zetia is safe to take during pregnancy. When you get Zetia from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. Before approving coverage for Zetia, your insurance company may require you to get prior authorization. Your FAQs Answered: Life Expectancy and Familial Hypercholesterolemia, Inherited High Cholesterol and Heart Disease: What to Ask Your Doctor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Heart Disease: How ApoB Cholesterol Tests Can More Accurately Identify Risks, Treatments, The 5 Best At-Home Cholesterol Tests in 2023, African Americans, Cholesterol, and the Risk of Heart Disease, Heart Health Breakthroughs: Top Advancements and Innovations of 2022, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, what dose of drug you were taking when you had the side effect, how soon after starting that dose you had the side effect, what your symptoms were from the side effect, what other medications you were also taking, any other information you feel is important, taking other medications, especially high dose statin drugs. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. It isnt known how often this side effect occurred with Zetia in clinical studies. Side effects may be more likely in older adults. If you develop liver problems, you may be more likely to experience side effects with Zetia. * For more information about this side effect, see " Zetia: Side effects explained " below. 22% in people who used Zetia with fenofibrate, 20% in people who used Zetia with fenofibrate, people who used Zetia with atorvastatin or simvastatin had their LDL levels reduced by an average of 21% to 27% (the percentage varied depending on the dosage used), people who used atorvastatin or simvastatin alone had their LDL levels reduced by an average of 7%, people who used Zetia had their sitosterol levels decreased by an average of 21% and their campstrol levels decreased by an average of 24%, people who used a placebo had their sitosterol levels decreased by an average of 4% and their campstrol levels decreased by an average of 3%, bile acid sequestrants, such as cholestyramine (Prevalite, Questran), colesevelam (Welchol), and colestipol (Colestid), statins, such as atorvastatin (Lipitor), rosuvastatin (Crestor), and simvastatin (Zocor), Both Zetia and Lipitor are FDA-approved to treat the following conditions* in adults when used with a. 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