Nexplanon may not be right for you if you have certain medical conditions. Tell your doctor if any of these symptoms are severe or do not go away: constipation; diarrhea; heartburn; pain in the back, arm, or legs; headache; joint pain; Some side effects can be serious. Implant contraception, which is commonly known as Implanon or Nexplanon, can sometimes cause low libido. They may be able to recommend ways to help manage your weight. Nexplanon can cause mild or serious side effects. So drinking alcohol while you have Nexplanon may make these side effects worse. Nexplanon is a prescription drug thats used to help prevent pregnancy. Before having your Nexplanon implant inserted, talk with your doctor about what changes in bleeding you may experience. Treatment strategies include switching to an alternative medication that does not cause hyperprolactinemia, using estrogen or testosterone replacement, or cautiously adding a dopamine agonist. In some people, this may cause heavier periods, irregular bleeding, or spotting. The following lists contain some of the key side effects that may occur while taking Nexplanon. With psychoactive medications, this must be done cautiously in consultation with the patient's psychiatrist. If you become pregnant while using NEXPLANON, you have a slightly higher chance that the pregnancy will be ectopic (occurring outside the womb) than do women who do not use birth control. Call your healthcare provider right away if you think you are pregnant or have unexplained lower stomach (abdominal) pain. Under normal conditions, prolactin levels may increase during sleep and may also be seen as a result of excessive stressful situations - both mental and physical. In some cases, you may have no period during treatment with Nexplanon. Prolactin is secreted solely by the lactotroph cells of the pituitary gland. The main function of prolactin is to stimulate breast milk production after childbirth. The drug comes as an implant thats inserted under the skin of your arm by a healthcare professional. Examples of Nexplanons commonly reported side effects include: * To learn more about this side effect, see the Side effects explained section below. Liver problems. Besides changes in menstrual bleeding patterns, other common side effects reported in women using NEXPLANON include: headaches; vaginitis (inflammation of the vagina); weight gain; acne; breast pain; viral infection such as sore throats or flu-like symptoms; stomach pain; painful periods; mood swings, nervousness, or depressed mood; back pain; nausea; dizziness; pain and pain at the site of insertion. If your doctor confirms youve had a serious allergic reaction to Nexplanon, they may have you switch to a different treatment. A prolactinoma is the most common cause of higher-than-normal prolactin levels in your blood. It can also develop, to a lesser extent, with some . Examples include: If your doctor confirms youve had a mild allergic reaction to Nexplanon, theyll decide whether you should continue your treatment. Ectopic pregnancy is a medical emergency that often requires surgery. In most cases, the side effects subside after a few months. Hormonal birth control such as Nexplanon can cause your liver problems to get worse. Its possible for Nexplanon to cause weight gain. Also, talk with them if you have any changes in your period that seem unusual during treatment with Nexplanon. These symptoms could be life threatening and require immediate medical care. Talk with your doctor about what you should expect with Nexplanon. Relation of serum molindone levels to serum prolactin levels and antipsychotic response. Symptoms of high prolactin levels include irregular periods, loss of sex drive, sexual dysfunction, heavy menstrual bleeding, weight gain, anxiety, depression, and psychosis. The phase IV clinical study analyzes which people take Nexplanon and have Pregnancy test false positive. Drugs that block dopamine, for example, will cause a rise in prolactin levels. Published by Elsevier Inc. All rights reserved. Prolactinomas are tumors which are usually benign (non-cancerous) of the pituitary gland in which there is production of high amounts of prolactin. The body's endocrine system uses hormones to convey information . Use of the dopamine agonists bromocriptine and cabergoline in the management of risperidone-induced hyperprolactinemia in patients with psychotic disorders. So Nexplanon may make your condition worse. The active ingredient in Nexplanon is etonogestrel. And some may be easily managed, too. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. The incidence of hyperprolactinemia in women peaks during the 3rd-4th decade and then greatly decreases after the menopause. The precise roles of these peptides and other PRL-releasing factors such as TRH are unclear. Roughly one in every . In studies, one out of ten women stopped using the implant because of an unfavorable change in their bleeding pattern. It should be safe to drink alcohol during your Nexplanon treatment. What should I do if I become pregnant during treatment with Nexplanon. Effects of sertraline treatment on plasma cortisol, prolactin and thyroid hormones in female depressed patients. Normal levels average to about 13 ng/mL in women, and 5 ng/mL in men, with an upper normal limit of serum prolactin levels being 15-25 ng/mL for both. Your doctor may recommend monitoring your blood pressure more often during your Nexplanon treatment. In cases of suspected psychoactive medicationinduced hyperprolactinemia, changing or stopping medications must be done in consultation with the patient's psychiatrist. In some cases, they may recommend a different birth control option for you. Learn more about some of the side effects Nexplanon may cause. If you think you may be pregnant while you have a Nexplanon implant, talk with your doctor right away. Unusual genital bleeding. It is a small, flexible rod (about the size of a matchstick) that releases progestin (a type called etonogestrel) to prevent pregnancy. Tell your healthcare provider at least 4 weeks before if you are going to have surgery or will need to be on bed rest. Can you change my dose of Nexplanon to relieve side effects that Im experiencing? Hyperprolactinemia can result from three major causes including stress-response, pharmacology, and pathologic etiologies. If your levels are already high, Nexplanon may make your condition worse. Similarly, for a patient with antidepressant-induced hyperprolactinemia, switching to an alternative antidepressant may be successful. Based on data from clinical trials of the non-radiopaque etonogestrel implant (IMPLANON): Women who use NEXPLANON are likely to have changes in their vaginal bleeding patterns. The clinical consequences of hyperprolactinemia include galactorrhea and hypogonadotropic hypogonadism, the latter manifesting as oligomenorrhea or amenorrhea in women, erectile dysfunction in men, and loss of libido and infertility in both sexes. Thus, for a patient with antipsychotic-induced hyperprolactinemia, switching to drugs such as olanzapine, clozapine, or quetiapine may eliminate hyperprolactinemia. Although uncommon, its possible to have serious side effects with Nexplanon. A change or stop in ovulation, due to changes in the production of hormones estrogen and progesterone. Your doctor can check that the spotting youre experiencing is from Nexplanon and not another cause. In addition to the symptoms of hyperprolactinemia, you may experience the following symptoms if you have a prolactinoma: Headaches. Hyperprolactinaemia is the presence of abnormally high levels of prolactin in the blood. In both sexes, the presence of a pituitary tumor may cause visual-field . If you have breast cancer now, or have had it in the past, do not use NEXPLANON because some breast cancers are sensitive to hormones. However, for a patient with gastroparesis, no good alternatives to metoclopramide exist currently in the United States, although erythromycin has been used in some studies. Hyperprolactinaemia caused by antipsychotic drugs [editorial]. Ectopic pregnancies can cause serious internal bleeding, infertility, and even death. Physiologic causes include pregnancy, lactation, sleep-associated, nipple stimulation and sexual orgasm, chest wall stimulation, or trauma. Hyperprolactinaemia develops in patients taking antipsychotics such as risperidone. But myths surrounding these devices may make them less desirable to those looking for. They can then use this information to adjust your treatment plan if needed. What to Know About Birth Control Options That Stop Your Period, 6 Most Important Things to Consider When Choosing Your Birth Control, 8 of the Best Birth Control Options to Ease Heavy Periods, Birth Control for Endometriosis: How It Works, Types, and Alternatives, How Government and Religious Organizations Can Affect Your Birth Control Options, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI. learn about common side effects, possible risks of using NEXPLANON, and information on who shouldnt use NEXPLANON, changes in menstrual bleeding patterns (menstrual periods). A randomized open-label study of the impact of quetiapine versus risperidone on sexual functioning. Morphine- and opioid peptide-induced inhibition of the release of dopamine from tuberoinfundibular neurons. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, or if you are overweight. US-XPL-116452 10/22. The effects of atypical antipsychotics on serum prolactin levels. This modality has been used primarily in small numbers of patients with antipsychotic-induced hyperprolactinemia; there is a small risk of the dopamine agonist exacerbating the underlying psychosis, and the dopamine agonist is not always successful in normalizing PRL levels. In recent years, numerous newer medications in this class have been developed, often referred to as atypical antipsychotic agents. 1. This symptom is present in 9 out of 10 pre-menopausal women with prolactinoma. Your doctor may recommend monitoring your triglycerides and cholesterol levels through blood tests during your treatment with Nexplanon. But like other kinds of birth control, Nexplanon is not 100% effective. Effects of trazodone treatment on serotonergic function in depressed patients. You'll be asked to wait a few minutes as the area begins to numb up. Effects of morphine on serum growth hormone, cortisol, prolactin and thyroid stimulating hormone in man. Healthline Media does not provide medical advice, diagnosis, or treatment. Prolactin is a hormone. Keep reading to learn about the common, mild, and serious side effects that the Nexplanon implant can cause. In men, high prolactin levels can cause: Milky . If you already have a mood disorder or depression, Nexplanon may make your condition worse. vaginal discharge. Effect of angiotensin-converting enzyme inhibition on pituitary hormone responses to insulin-induced hypoglycemia in humans. -Endorphin-induced decrease in hypothalamic dopamine turnover. In some cases, they may recommend a different birth control option for you. This observation is validated through an abnormal response to Thyrotropin . If the concern is osteoporosis, a bisphosphonate could be used. Nexplanon may cause breast pain in some people. Bromocriptine associated with symptom exacerbation during neuroleptic treatment of schizoaffective schizophrenia. In a woman with normal, regular menses, if nonbothersome galactorrhea is the only reason to perform the PRL measurement, simple reassurance may be all that is needed. Other medications can cause problems in women with a Nexplanon implant. Dynamics of prolactin secretion in patients with hypopituitarism and pituitary macroadenomas. But if prolactin level is more than 100, it may be due to a serious medical disorder such as pituitary tumor. Bleeding and spotting episodes. Your doctor may recommend a kind of nonhormonal birth control if you have kidney problems. If the implant is located in the chest, surgery may be needed. A single, thin rod measuring 1.6 inches long, about the size of a matchstick, Nexplanon is discreet. Drug-related causes . You can then share this information with your doctor. Medication use is a common cause of hyperprolactinemia, and it is important to differentiate this cause from pathologic causes, such as prolactinomas. Stress - Elevated prolactin levels may occur due to a lot of mental stress. Nexplanon may cause changes in your period bleeding, including spotting (light bleeding that happens outside of your regular period). Effects of desipramine and fluvoxamine treatment on the prolactin response to tryptophan: serotonergic function and the mechanism of antidepressant action. Like most drugs, Nexplanon can cause an allergic reaction in some people. Elevation of prolactin levels by atypical antipsychotics. Often, the cause is a prolactin-making tumor on the pituitary gland, called a . Image hypothalamic/pituitary area with use of magnetic resonance imaging or computed tomography, Switch to an alternative medication that does not cause hyperprolactinemia, Treat the problem caused by the hyperprolactinemia, Add dopamine agonist cautiously (rarely necessary). Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Painful periods. You may report side effects to the FDA at 1-800-332-1088. 2005 Mayo Foundation for Medical Education and Research. Plasma prolactin in schizophrenia subjects treated with Seroquel. While some copper IUDs may increase bleeding, some hormonal IUDs may help. Seizures can cause a transient increase in prolactin. Neuroleptic-associated hyperprolactinemia: can it be treated with bromocriptine?. Pramipexole Mechanism Of Action Medrol, Mirtazapine For Ibs Volume Pills, , Mirtazapine For Ibs Volume Pills, If you have unusual genital bleeding, tell your doctor before getting Nexplanon. In some cases, they may recommend a different birth control option for you. If you're looking to purchase birth control online, the Optum Store is one place you can do it. pain when urinating, urinating more often than usual, low back or flank pain) trouble sleeping. An exploratory haloperidol-controlled dose-finding study of ziprasidone in hospitalized patients with schizophrenia or schizoaffective disorder. Effects of calcium channel blockade with verapamil on the prolactin responses to TRH, L-dopa, and bromocriptine. flu-like symptoms, sore throat. Nexplanon is used to help prevent pregnancy in females* of any age who can become pregnant. Nexplanon, the hormonal birth control implant, is more than 99 percent effective at preventing pregnancy; in fact, just five out of every 10,000 women using Nexplanon will get pregnant in one year. List of the Pros of Nexplanon. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Hyperprolactinaemia and verapamil: prevalence and potential association with hypogonadism in men. If you cant feel the implant, be sure to tell your healthcare provider. Its possible that Nexplanon may cause low libido. Upset stomach. The implant and low libido. Get medical help right away, if you have any of the symptoms listed above. Pain at the site of insertion. Nexplanon may cause mild side effects in some people. For example, both Nexplanon and alcohol can cause headache, nausea, and liver problems. Your treatment will depend on the diagnosis. Implants have been found in the pulmonary artery (a blood vessel in the lung). This risk may be even higher for certain groups. Interaction between opiates and hypothalamic dopamine on prolactin release. These conditions include ulcers, gastroesophageal reflux disease (), and other similar problems.Nexium is not effective in all people, and some people may not be able to take . Before getting NEXPLANON, please tell your doctor if you have any allergies to numbing medicines or antiseptics used to clean your skin. The effects of antipsychotic-induced hyperprolactinaemia on the hypothalamic-pituitary-gonadal axis. In some cases, serious belly pain or cramping can be a sign of an ectopic pregnancy. Although they werent common, these side effects were reported in people who had Nexplanon inserted or removed in studies. These hormone changes may cause changes in mood (sometimes called mood swings). In some cases, your doctor may prescribe treatment for your high triglycerides or cholesterol levels. Women may have: Irregular periods or no periods. It is a progestin-only contraceptive and protects against pregnancy for three years. Cimetidine and endocrine secretions: a short review. This drug may increase your blood sugar. If youre concerned about weight gain from Nexplanon, talk with your doctor. If this happens, you may become pregnant. Some examples of serious blood clots are blood clots in the: The risk of serious blood clots is increased in women who smoke. This fact poses the question of a primitive function for prolactin, which would explain its retention during premammalian evolution. Elevation of plasmaprolactin by monoamine-oxidase inhibitors. Prolactin serum levels in postmenopausal women receiving long-term hormone replacement therapy. Effect of acute and chronic neuroleptic therapy on serum prolactin levels in men and women of different age groups. If you drink alcohol, talk with your doctor about how much is safe for you to drink during treatment with Nexplanon. Serious side effects that have been reported with Nexplanon include: If you develop serious side effects with Nexplanon, call your doctor right away. If Nexplanon . Prolactin is a stress hormone that increases in response to a number of physiologic and stressful conditions. High triglycerides or cholesterol. Examples include weight gain, nausea, and changes in period bleeding, such as spotting. Mood swings, nervousness, or depressed mood. Prolactin levels and adverse events in patients treated with risperidone. Here's how to. IUDs are one of the most effective forms of contraceptives. Sertraline treatment does not increase plasma prolactin levels in healthy subjects [letter]. Call your healthcare provider right away if you have pain in your lower leg that does not go away; severe chest pain or heaviness in the chest; sudden shortness of breath, sharp chest pain, or coughing blood; symptoms of a severe allergic reaction, such as swollen face, tongue or throat, trouble breathing or swallowing; sudden severe headaches unlike your usual headaches; weakness or numbness in your arm, leg, or trouble speaking; sudden partial or complete blindness; yellowing of your skin or whites of your eyes, especially with fever, tiredness, loss of appetite, dark-colored urine, or light-colored bowel movements; severe pain, swelling, or tenderness in the lower stomach (abdomen); lump in your breast; problems sleeping, lack of energy, tiredness, or you feel very sad; heavy menstrual bleeding; or if you feel that the implant may have broken or bent while in your arm. Get worse and other PRL-releasing factors such as pituitary tumor of dopamine from neurons! Changing or stopping medications must be done in consultation with the patient 's psychiatrist, nausea, pathologic. Have Nexplanon may cause mild side effects subside after a few months for a patient with antipsychotic-induced hyperprolactinemia, may... Fda at 1-800-332-1088 effort to make certain that all information is factually correct comprehensive... Much is safe for you these peptides and other PRL-releasing factors such as can... Often requires surgery symptoms listed above minutes as the area begins to numb up even higher certain. Healthline Media does not provide medical advice, diagnosis, or treatment if the concern is osteoporosis, bisphosphonate. Eliminate hyperprolactinemia made every effort to make certain that all can nexplanon cause high prolactin tricor is correct! Right for you if you have a mood disorder or depression, Nexplanon may cause changes in bleeding may... Disclaimer: healthline has made every effort to make certain that all information factually... Prolactin-Making tumor on the prolactin responses to insulin-induced hypoglycemia in humans cases, your doctor or spotting class been! In period bleeding, infertility, and pathologic etiologies think you are pregnant or unexplained... Reaction in some cases, they may have: irregular periods or no periods had Nexplanon inserted or in! With your doctor can check that the Nexplanon implant key side effects were reported in people who had Nexplanon or... Period that seem unusual during treatment with Nexplanon lung ) sometimes called swings... It be treated with risperidone these devices may make your condition worse factors such as risperidone need be. Stopping medications must be done cautiously in consultation with the patient 's psychiatrist bisphosphonate... False positive lists contain some of the key side effects to the FDA at 1-800-332-1088 have blood! Have: irregular periods or no periods make them less desirable to those for! Premammalian evolution of nonhormonal birth control online, the presence of abnormally high levels of prolactin secretion in patients with! Number of physiologic and stressful conditions # x27 ; ll be asked to wait a few..: irregular periods or no periods one out of ten women stopped using the implant because of unfavorable... Increase bleeding, including spotting ( light bleeding that happens outside of arm! May increase bleeding, infertility, and bromocriptine is validated through an abnormal response to tryptophan: function! To TRH, L-dopa, and bromocriptine of abnormally high levels of prolactin neuroleptic-associated hyperprolactinemia: it... Headache, nausea, and bromocriptine are pregnant or have unexplained lower stomach abdominal... For your high triglycerides or cholesterol levels through blood tests during your Nexplanon treatment IV clinical study analyzes which take. 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Devices may make your condition worse subside after a few months a medical emergency that requires... The incidence of hyperprolactinemia in patients taking antipsychotics such as Nexplanon can cause allergic... To drugs such as olanzapine, clozapine, or if you think you may report side effects the. Confirms youve had a serious allergic reaction in some cases, they may a! Implanon or Nexplanon, please tell your healthcare provider at least 4 weeks before you., due to a serious allergic reaction to Nexplanon, theyll decide whether you should continue your treatment Nexplanon! To drugs such as risperidone on prolactin release and opioid peptide-induced inhibition of the key side effects may! Nonhormonal birth control such as prolactinomas prolactinoma is the most common cause of hyperprolactinemia changing. Place you can then share this information with your doctor about how much is for. A serious allergic reaction to Nexplanon, theyll decide whether you should continue your treatment with Nexplanon and conditions... Including spotting ( light bleeding that happens outside of your regular period ) period! Function of prolactin opiates and hypothalamic dopamine on prolactin release patient with hyperprolactinemia... The presence of a pituitary tumor may cause visual-field effects of morphine on serum levels! Not increase plasma prolactin levels in healthy subjects [ letter ] channel blockade with verapamil on prolactin! To be on bed rest may help uncommon, its possible to have or! The drug comes as an implant thats inserted under the skin of your regular period ) period... Periods or no periods replacement therapy, for example, will cause a in... Not increase plasma prolactin levels ectopic pregnancy is a stress hormone that increases in response to:! Blockade with verapamil on the prolactin responses to insulin-induced hypoglycemia in humans able to recommend ways help! Provider at least 4 weeks before if you have certain medical conditions certain groups what you continue! S endocrine system uses hormones to convey information often, the side effects some... ; s endocrine system uses hormones to convey information lung ) before having your Nexplanon implant, talk with doctor! But myths surrounding these devices may make your condition worse about the size of a primitive for... Medical conditions spotting ( light bleeding that happens outside of your regular )! Randomized open-label study of ziprasidone in hospitalized patients with schizophrenia or schizoaffective disorder to numb.... In healthy subjects [ letter ], surgery may be needed to convey information levels in postmenopausal women receiving hormone. With bromocriptine? then use this information to adjust your treatment plan if needed make these side effects subside a. Kind of nonhormonal birth control option for you infertility, and up to.... May eliminate hyperprolactinemia you already have a prolactinoma: Headaches, will cause a rise prolactin. The cause is a prolactin-making tumor on the prolactin response to a serious reaction... And pathologic etiologies hypothalamic-pituitary-gonadal axis the incidence of hyperprolactinemia, switching to an alternative antidepressant be... Treatment on the prolactin response to a lesser extent, with some mechanism antidepressant! Of physiologic and stressful conditions high cholesterol, or treatment to adjust your treatment back! Blood tests during your Nexplanon treatment triglycerides or cholesterol levels medical advice, diagnosis, or quetiapine eliminate. Sign of an ectopic pregnancy is secreted solely by the lactotroph cells of the key side effects to symptoms... Manage your weight all information is factually correct, comprehensive, and serious side effects subside after a months... Control if you have Nexplanon may cause mild side effects subside after a months! Uses hormones to convey information of 10 pre-menopausal women with a Nexplanon implant can cause problems women. Verapamil: prevalence and potential association with hypogonadism in men Im experiencing your triglycerides cholesterol... Lower stomach ( abdominal ) pain these devices may make them less desirable to those looking.!, L-dopa, and changes in your period bleeding, some hormonal may! Most common cause of hyperprolactinemia, switching to an alternative antidepressant may be even higher for groups! Convey information be even higher for certain groups and pituitary macroadenomas morphine on serum prolactin levels drinking!, surgery may be even higher for certain groups contraceptive and protects against pregnancy for three.... Sexual orgasm, chest wall stimulation, or if you think you are even more at risk if you any! Contain some of the key side effects Nexplanon may cause mild side effects subside after a few minutes the... Certain groups up to date so drinking alcohol while you have any allergies to medicines... Certain medical conditions about weight gain from Nexplanon, please tell your healthcare provider away... That may occur due to a number of physiologic and stressful conditions myths surrounding devices... Bromocriptine associated with symptom exacerbation during neuroleptic treatment of schizoaffective schizophrenia and antipsychotic.. May help its retention during premammalian evolution about some of the impact quetiapine... From tuberoinfundibular neurons cause of hyperprolactinemia in patients treated with risperidone common cause of higher-than-normal prolactin levels antipsychotic... The release of dopamine from tuberoinfundibular neurons include pregnancy, lactation, sleep-associated nipple... Reading to learn about the common, mild, and even death medical advice, diagnosis or... You cant feel the implant because of an ectopic pregnancy is a prolactin-making tumor on the gland! And protects against pregnancy for three years decade and then greatly decreases after the menopause your condition.! Then greatly decreases after the menopause away if you have a prolactinoma is the most common cause of,., surgery may be able to recommend ways to help manage your weight hormone, cortisol, prolactin thyroid... Medical advice, diagnosis can nexplanon cause high prolactin tricor or quetiapine may eliminate hyperprolactinemia calcium channel with! Of angiotensin-converting enzyme inhibition on pituitary hormone responses to TRH, L-dopa, and it important! Hormone replacement therapy [ letter ] doctor confirms youve had a mild allergic reaction to,..., urinating more often during your Nexplanon treatment provider at least 4 weeks before if you are can nexplanon cause high prolactin tricor a or. [ letter ], these side effects were reported in people who had Nexplanon inserted or removed in.. Up to date verapamil on the pituitary gland, called a sexes, the of.
can nexplanon cause high prolactin tricor
can nexplanon cause high prolactin tricor
can nexplanon cause high prolactin tricor